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- Title
Melatonin Effects in Methylphenidate Treated Children with Attention Deficit Hyperactivity Disorder: A Randomized Double Blind Clinical Trial.
- Authors
Mohammadi, Mohammad Reza; Ali Mostafavi, Seyed; Ali Keshavarz, Seyed; Reza Eshraghian, Mohammad; Hosseinzadeh, Payam; Hosseinzadeh-Attar, Mohammad Javad; Ali Kooshesh, Seyed Mohammad; Chamari, Maryam; Akhondzadeh, Shahin
- Abstract
Objective: The aim of this study was to determine melatonin effects on sleep patterns, symptoms of hyperactivity and attention deficiency in children with attention-deficit hyperactivity disorder (ADHD). Methods: Children with age range of 7-12 years who had a combined form of ADHD were randomly divided in to 2 groups according to gender blocks. One group took melatonin (3 or 6mg) combined with methylphenidate (Ritalin) (1mg/kg), and the other group took placebo combined with methylphenidate (1mg/kg). ADHD rating scale and sleep patterns questionnaires were completed. Research hypotheses were assessed at the baseline, the second, fourth and eighth weeks after the treatment. Results: The mean sleep latency and total sleep disturbance scores were reduced in melatonin group, while the scores increased in the placebo group (p≥0.05). Data analysis, using ANOVA with repeated measures, did not show any statistically significant differences between the two groups in ADHD scores. Conclusion: Administration of melatonin along with methylphenidate can partially improve symptoms of sleep disturbance. However, it does not seem to reduce attention deficiency and hyperactivity behavior of children with ADHD.
- Publication
Iranian Journal of Psychiatry, 2012, Vol 7, Issue 2, p87
- ISSN
1735-4587
- Publication type
Journal Article