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- Title
A new regulator of the vacuolar H<sup>+</sup>-ATPase in the kidney.
- Authors
Eladari, Dominique; Teulon, Jacques
- Abstract
Xu et al. identify Slc26a11, a novel member of the Slc26 anion exchanger family, as an electrogenic (Cl−)n/HCO3− exchanger. Functional characterization of this transporter suggests that Slc26a11 mediates classical electroneutral Cl−/HCO3− exchange but also exhibits an electrogenic Cl− conductance. In the kidney, Slc26a11 colocalizes with the vacuolar H+-ATPase in intercalated cells, emphasizing the cooperation of the proton pump with chloride transporters.
- Subjects
KIDNEY diseases; ADENOSINE triphosphate; PROTON pump inhibitors; EUKARYOTIC cells; ANIONS
- Publication
Kidney International, 2011, Vol 80, Issue 9, p907
- ISSN
0085-2538
- Publication type
Opinion
- DOI
10.1038/ki.2011.220