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- Title
Resistance to Dual Nucleoside Reverse-Transcriptase Inhibitors in Children Infected with HIV Clade A/E.
- Authors
Lolekha, Rangsima; Sirivichayakul, Sunee; Siangphoe, Umaporn; Pancharoen, Chitsanu; Kaewchana, Suchada; Apateerapong, Wichitra; Mahanontharit, Apicha; Chotpitayasunondh, Tawee; Ruxrungtham, Kiat; Phanuphak, Praphan; Ananworanich, Jintanat
- Abstract
The prevalence of nucleoside reverse-transcriptase inhibitor (NRTI) mutations was determined among 95 human immunodeficiency virus-infected Thai children who were treated with dual nucleoside reverse-transcriptase inhibitors. Almost all children had resistance to at least 1 NRTI, and approximately half of the children had resistance to multiple NRTIs. Cross-resistance to stavudine and azidothymidine was universal.
- Subjects
REVERSE transcriptase; NUCLEOSIDES; AZIDOTHYMIDINE; IMMUNITY; DRUG resistance; HIV infections
- Publication
Clinical Infectious Diseases, 2005, Vol 40, Issue 2, p309
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1086/427026