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- Title
HLA antigens in patients with unexplained hepatitis following halothane anesthesia.
- Authors
OTSUKA, S.; YAMAMOTO, M.; KASUYA, S.; OHTOMO, H.; YAMAMOTO, Y.; YOSHIDA, T. O.; AKAZA, T.
- Abstract
We examined HLA-A,B,C and DR locus antigens in 38 Japanese patients who had recovered from halothane hepatitis. The patients were divided into two subgroups, i.e. jaundice and non-jaundice groups, because the clinical features were quite different in each. DR2 was positive in 14 (58.3%) of 24 patients with jaundice, compared with 281 (33.6%) of the 837 Japanese healthy controls (chi-square with Yates' correction = 5.30, relative risk = 2.77, P less than 0.025). Conversely, Bw44 was increased in non-jaundice patients (50.0%), compared with 157 (12.7%) of the 1234 Japanese healthy controls (chi-square with Yates' correction = 13.75, relative risk = 6.86, P less than 0.001). The haplotype frequency (Hf) of Aw24-Bw52-DR2 was high in the patients with jaundice (Hf = 0.2362), while it was zero in the patients without jaundice (P less than 0.0042). These data suggest that the two groups of halothane hepatitis have different genetic backgrounds.
- Publication
Acta Anaesthesiologica Scandinavica, 1985, Vol 29, Issue 5, p497
- ISSN
0001-5172
- Publication type
journal article
- DOI
10.1111/j.1399-6576.1985.tb02242.x