We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Low expression of NSD1, NSD2, and NSD3 define a subset of human papillomavirus-positive oral squamous carcinomas with unfavorable prognosis.
- Authors
Gameiro, Steven F.; Ghasemi, Farhad; Zeng, Peter Y. F.; Mundi, Neil; Howlett, Christopher J.; Plantinga, Paul; Barrett, John W.; Nichols, Anthony C.; Mymryk, Joe S.
- Abstract
Background: Frequent mutations in the nuclear receptor binding SET domain protein 1 (NSD1) gene have been observed in head and neck squamous cell carcinomas (HNSCC). NSD1 encodes a histone 3 lysine-36 methyltransferase. NSD1 mutations are correlated with improved clinical outcomes and increased sensitivity to platinum-based chemotherapy agents in human papillomavirus-negative (HPV-) tumors, despite weak T-cell infiltration. However, the role of NSD1 and related family members NSD2 and NSD3 in human papillomavirus-positive (HPV+) HNSCC is unclear. Methods: Using data from over 500 HNSCC patients from The Cancer Genome Atlas (TCGA), we compared the relative level of mRNA expression of NSD1, NSD2, and NSD3 in HPV+ and HPV- HNSCC. Correlation analyses were performed between T-cell infiltration and the relative level of expression of NSD1, NSD2, and NSD3 mRNA in HPV+ and HPV- HNSCC. In addition, overall survival outcomes were compared for both the HPV+ and HPV- subsets of patients based on stratification by NSD1, NSD2, and NSD3 expression levels. Results: Expression levels of NSD1, NSD2 or NSD3 were not correlated with altered lymphocyte infiltration in HPV+ HNSCC. More importantly, low expression of NSD1, NSD2, or NSD3 correlated with significantly reduced overall patient survival in HPV+, but not HPV- HNSCC. Conclusion: These results starkly illustrate the contrast in molecular features between HPV+ and HPV- HNSCC tumors and suggest that NSD1, NSD2, and NSD3 expression levels should be further investigated as novel clinical metrics for improved prognostication and patient stratification in HPV+ HNSCC.
- Subjects
CANCER patients; CARRIER proteins; STATISTICAL correlation; GENE expression; HUMAN genome; MESSENGER RNA; HEAD &; neck cancer; PAPILLOMAVIRUS diseases; SQUAMOUS cell carcinoma; SURVIVAL analysis (Biometry); BIBLIOGRAPHIC databases; NUCLEAR proteins; EPIGENOMICS; DISEASE complications
- Publication
Infectious Agents & Cancer, 2021, Vol 16, Issue 1, p1
- ISSN
1750-9378
- Publication type
Article
- DOI
10.1186/s13027-021-00347-6