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- Title
Involvement of steroids in anti-inflammatory effects of PK11195 in a murine model of pleurisy.
- Authors
da Silva, Marcelo Barreto Spillere; Farges, Roseli Coimbra; Fröde, Tânia Silvia
- Abstract
BACKGROUND: Studies on peripheral benzodiazepine receptor function have yielded a diverse list of activities of which the anti-Inflammatory effects need to be further examined. Aims: To evaluate the role of steroids, nitric oxide and adenosine-deaminase In the anti-Inflammatory effect of P1(11195. Methods: Pleurisy was Induced by intrapleural Injection of carrageenan In mice pit-treated or not with PK1 1195. Leukocytes, exudation, adenosine-deaminase (ADA) activity and nitric oxide (No) level were measured. Steroid Involvement was evaluated by pre- treatment with n,i-aminogluthetimide before PK11195. Results: Leukocytes, exudation and NO levels were reduced by PK11195 In the early (4 h) phase. In the late (48 h) phase, P1(11195 decreased leukocytes and ADA activity. D,L-aminogluthetimide reversed the effect of PK11195 on exudate (4 h), as well as total and differential leukocytes and NO levels (48 h). Conclusions: Steroids, NO and ADA are Implicated In the anti-Inflammatory action of P1(11195.
- Subjects
STEROIDS; ANTI-inflammatory agents; PLEURISY; PLEURA diseases; NITRIC oxide; ADENOSINES
- Publication
Mediators of Inflammation, 2004, Vol 13, Issue 2, p93
- ISSN
0962-9351
- Publication type
Article
- DOI
10.1080/09629350410001688486