We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Myeloperoxidase and adenosine-deaminase levels in the pleural fluid leakage induced by carrageenan in the mouse model of pleurisy.
- Authors
Silvia Fröde, Tânia; Medeiros, Y. S.
- Abstract
Background: Although myeloperoxidase (MPO) and adenosine-deaminase (ADA) levels are markers of activated leukocytes, both enzymes have not been currently addressed in inflammation models. Aims: This study evaluates whether the concentrations of these enzymes are significantly correlated with the content of leukocytes in a pleurisy model. Methods: The pleurisy was induced by carrageenan (1%) in mice, and the parameters analyzed 4 and 48 h after. Results: After the induction of inflammation (4 h), MPO and ADA levels peaked in parallel to neutrophils (p < 0.01). Regarding the second phase of pleurisy (48 h), the highest concentrations of ADA were detected in parallel to the highest levels of mononuclears (p< 0.01). At this time, MPO levels and neutrophils remained elevated, although at lower levels than those found at 4 h. A significant positive correlation was found among neutrophils and MPO, and mononuclears and ADA (p< 0.01). Conclusions: These findings support the evidence that both enzymes are markers of the inflammatory process, and provide new tools for a better understanding of the immunoregulatory pathways that occur in inflammation.
- Subjects
ENZYMES; LEUCOCYTES; NEUTROPHILS
- Publication
Mediators of Inflammation, 2001, Vol 10, Issue 4, p223
- ISSN
0962-9351
- Publication type
Article
- DOI
10.1080/09629350120080429