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- Title
Loss of LRP1 in Adult Neural Stem Cells Impairs Migration to Ischemic Lesions.
- Authors
Dietert, Kristi; Mahesula, Swetha; Hegde, Sheetal; Verschelde, John; Reed, Pamela; Sprague, Shane; Kokovay, Erzsebet; Sayre, Naomi L
- Abstract
After ischemia, cells in the brain parenchyma upregulate stromal derived factor 1 (SDF1), driving chemokine receptor CXCR4-mediated migration of adult neural stem cells to the ischemic injury. We discovered a novel regulator of CXCR4 in neural stem cells, low-density lipoprotein receptor related protein 1 (LRP1). We used Nestin-driven knockout of LRP1 and induction of td-tomato in neural stem cells of adult mice. We observed reduced localization of td-tomato positive cells to the lesion, and find disrupted CXCR4-mediated neural stem cell migration in vitro, which is likely driven by LRP1-mediated loss of CXCR4 expression in vivo. Our results suggest that LRP1 is a novel regulator of CXCR4 in neural stem cells. This heretofore unknown interaction between LRP1 and CXCR4 could have significant consequences for multiple aspects of neural stem cell physiology.
- Subjects
NEURAL stem cells; CELL migration; LIPOPROTEIN receptors; CELL physiology; PROTEIN receptors; CXCR4 receptors
- Publication
Stem Cells, 2023, Vol 41, Issue 6, p570
- ISSN
1066-5099
- Publication type
Article
- DOI
10.1093/stmcls/sxad034