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- Title
Emotion recognition in individuals with cocaine use disorder: the role of abstinence length and the social brain network.
- Authors
Rabin, Rachel A.; Parvaz, Muhammad A.; Alia-Klein, Nelly; Goldstein, Rita Z.
- Abstract
Rationale: Emotion recognition is impaired in drug addiction. However, research examining the effects of cocaine use on emotion recognition yield mixed evidence with contradictory results potentially reflecting varying abstinence durations. Objectives: Therefore, we investigated emotion recognition and its neural correlates in individuals with cocaine use disorder (CUD) parsed according to abstinence duration. Methods: Emotion recognition performance was compared between current cocaine users (CUD + , n = 28; cocaine-positive urine), short-term abstainers (CUD-ST, n = 23; abstinence < 6 months), long-term abstainers (CUD-LT, n = 20; abstinence ≥ 6 months), and controls (n = 45). A sample subset (n = 73) underwent structural magnetic resonance imaging to quantify regional gray matter volume (GMV) using voxel-based morphometry. Results: CUD + demonstrated greater difficulty recognizing happiness than CUD-ST and controls, and sadness and fear compared to controls (p < 0.01). For fear, CUD-ST also performed worse than controls (p < 0.01), while no differences emerged between CUD-LT and controls. Whole-brain analysis revealed lower GMV in the bilateral cerebellum in CUD + compared to CUD-LT and controls; a similar pattern was observed in the amygdala (CUD + < CUD-LT) (pFWE < 0.01). Collapsed across all participants, poorer recognition for happiness was associated with lower right cerebellar GMV (pFWE < 0.05). Conclusions: Emotion recognition is impaired with current cocaine use, and selective deficits (in fear) may persist with up to 6 months of abstinence. Lower cerebellar GMV may underlie deficits in positive emotion recognition. Interventions targeting emotional-social-cognitive deficits, especially among active users, may enhance treatment success for individuals with CUD.
- Subjects
BRAIN physiology; CEREBELLUM physiology; SUBSTANCE abuse &; psychology; RECOGNITION (Psychology); DRUG abstinence; HAPPINESS; TIME; SELF-control; DRUG withdrawal symptoms; MAGNETIC resonance imaging; FEAR; COMPARATIVE studies; COCAINE; DESCRIPTIVE statistics; EMOTIONS; SOCIAL skills; EMOTION regulation; AMYGDALOID body
- Publication
Psychopharmacology, 2022, Vol 239, Issue 4, p1019
- ISSN
0033-3158
- Publication type
Article
- DOI
10.1007/s00213-021-05868-x