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- Title
The role of MIF in periodontitis: A potential pathogenic driver, biomarker, and therapeutic target.
- Authors
Fang, Tongfeng; Liu, Liu; Song, Dongzhe; Huang, Dingming
- Abstract
Objective: Periodontitis is an inflammatory disease that involves an imbalance in the oral microbiota, activation of inflammatory and immune responses, and alveolar bone destruction. Macrophage migration inhibitory factor (MIF) is a versatile cytokine involved in several pathological reactions, including inflammatory processes and bone destruction, both of which are characteristics of periodontitis. While the roles of MIF in cancer and other immune diseases have been extensively characterized, its role in periodontitis remains inconclusive. Results: In this review, we describe a comprehensive analysis of the potential roles of MIF in periodontitis from the perspective of immune response and bone regulation at the cellular and molecular levels. Moreover, we discuss its potential reliability as a novel diagnostic and therapeutic target for periodontitis. Conclusion: This review can aid dental researchers and clinicians in understanding the current state of MIF‐related pathogenesis, diagnosis, and treatment of periodontitis.
- Subjects
PERIODONTITIS treatment; THERAPEUTIC use of cytokines; CELL migration inhibition; BONE resorption; MACROPHAGES; INFLAMMATORY mediators; DENTAL research; PERIODONTAL disease; MOLECULAR biology; PERIODONTITIS; BIOMARKERS
- Publication
Oral Diseases, 2024, Vol 30, Issue 3, p921
- ISSN
1354-523X
- Publication type
Article
- DOI
10.1111/odi.14558