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- Title
Genetic Control of the Murine Cell-Mediated Immune Response In Vivo.
- Authors
Davis, S.
- Abstract
Various inbred and congenic strains of mice were immunized with the linear terpolymer L-glutamic acid60-L-alanine30-L-tyrosine60 (GAT). Using a radioisotopic footpad assay to measure cell-mediated immunity in vivo, mice with H-2a, H-2b, H-2d, and H-2k histocompatibility alleles showed a positive reaction, whereas mice with H-2P and H-23 alleles failed to respond. The ability of ‘responder’ lymphocytes to show an immune response resides in the thymus-derived (T) lymphocyte population. Unfractionated spleen cells from H-2q nonresponder mice, on transfer, showed no reactivity, whereas T-cell-enriched preparations were active
- Subjects
GENETICS; MICE; ANIMAL models in research; IMMUNE response; IMMUNOLOGY; CELLULAR immunity
- Publication
Scandinavian Journal of Immunology, 1975, Vol 4, Issue 3, p253
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1975.tb02624.x