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- Title
Immunoglobulin Synthesis In Vitro by Cerebro-spinal Fluid Cells in Patients with Multiple Sclerosis.
- Authors
Sandberg-Wollheim, M.
- Abstract
Incubated cerebrospinal fluid (CSF) cells from patients with multiple sclerosis synthesized IgG and IgA in vitro. The synthesized IgG had an oligoclonal distribution and showed the same electrophoretic pattern as the IgG of the CSF. The amount synthesized was greater during exacerbations than during remissions. Blood lymphocytes from the same patients synthesized an IgG in vitro that showed a completely different electrophoretic pattern. The amount IgG synthesized by the blood lymphocytes was less than the amount synthesized by the CSF cells. The results demonstrate that at least part of the oligoclonal IgG of the CSF of patients with multiple sclerosis is synthesized intrathecally and suggest that the CSF cells are antigenically stimulated in vivo.
- Subjects
IMMUNOGLOBULIN G; VIRUS diseases; MULTIPLE sclerosis; LEUCOCYTES; LYMPHOCYTES; CEREBROSPINAL fluid
- Publication
Scandinavian Journal of Immunology, 1974, Vol 3, Issue 6, p717
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1974.tb01307.x