We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association between serum selenium level and conversion of bacteriological tests during antituberculosis treatment.
- Authors
Lima de Moraes, Milena; de Paula Ramalho, Daniela Maria; Neves Delogo, Karina; Fernandes Campino Miranda, Pryscila; Denites Duarte Mesquita, Eliene; Marinho de Melo Guedes de Oliveira, Hedi; Ruffino-Netto, Antônio; de Almeida, Paulo César; Hauser-Davis, Rachel Ann; Calixto Campos, Reinaldo; Lineu Kritski, Afrânio; de Oliveira, Martha Maria
- Abstract
Objective: To determine whether serum selenium levels are associated with the conversion of bacteriological tests in patients diagnosed with active pulmonary tuberculosis after eight weeks of standard treatment. Methods: We evaluated 35 healthy male controls and 35 male patients with pulmonary tuberculosis, the latter being evaluated at baseline, as well as at 30 and 60 days of antituberculosis treatment. For all participants, we measured anthropometric indices, as well as determining serum levels of albumin, C-reactive protein (CRP) and selenium. Because there are no reference values for the Brazilian population, we used the median of the serum selenium level of the controls as the cut-off point. At 30 and 60 days of antituberculosis treatment, we repeated the biochemical tests, as well as collecting sputum for smear microscopy and culture from the patients. Results: The mean age of the patients was 38.4 ± 11.4 years. Of the 35 patients, 25 (71%) described themselves as alcoholic; 20 (57.0%) were smokers; and 21 (60.0%) and 32 (91.4%) presented with muscle mass depletion as determined by measuring the triceps skinfold thickness and arm muscle area, respectively. Of 24 patients, 12 (39.2%) were classified as moderately or severely emaciated, and 15 (62.5%) had lost > 10% of their body weight by six months before diagnosis. At baseline, the tuberculosis group had lower serum selenium levels than did the control group. The conversion of bacteriological tests was associated with the CRP/albumin ratio and serum selenium levels 60 days after treatment initiation. Conclusions: Higher serum selenium levels after 60 days of treatment were associated with the conversion of bacteriological tests in pulmonary tuberculosis patients.
- Subjects
BLOOD serum analysis; SELENIUM in the body; ANTITUBERCULAR agents; TUBERCULOSIS diagnosis; TUBERCULOSIS treatment; C-reactive protein; BACTERIOLOGY
- Publication
Brazilian Journal of Pulmonology / Jornal Brasileiro de Pneumologia, 2014, Vol 40, Issue 3, p269
- ISSN
1806-3713
- Publication type
Article
- DOI
10.1590/S1806-37132014000300010