Found: 41
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Whole‐brain microscopy reveals distinct temporal and spatial efficacy of anti‐Aβ therapies.
- Published in:
- EMBO Molecular Medicine, 2023, v. 15, n. 1, p. 1, doi. 10.15252/emmm.202216789
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- Publication type:
- Article
Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease.
- Published in:
- 2011
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- Publication type:
- journal article
Loss of TDP‐43 oligomerization or RNA binding elicits distinct aggregation patterns.
- Published in:
- EMBO Journal, 2023, v. 42, n. 17, p. 1, doi. 10.15252/embj.2022111719
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- Publication type:
- Article
Phospho-tau–specific vaccine for the treatment of tau pathology
- Published in:
- 2012
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- Publication type:
- Abstract
Comparison of toxic beta-amyloid oligomer inhibitors for rescuing memory deficits in APP transgenic mice
- Published in:
- 2012
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- Publication type:
- Abstract
P1-036: Genetic modulation of vascular amyloid in APPDutch mice
- Published in:
- 2006
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- Publication type:
- Abstract
P1-036: Genetic modulation of vascular amyloid in APPDutch mice
- Published in:
- 2006
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- Publication type:
- Abstract
Tau Seeds in Extracellular Vesicles Induce Tau Accumulation in Degradative Organelles of Cells.
- Published in:
- DNA & Cell Biology, 2021, v. 40, n. 9, p. 1185, doi. 10.1089/dna.2021.0485
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- Publication type:
- Article
β-site specific intrabodies to decrease and prevent generation of Alzheimer's Aβ peptide.
- Published in:
- 2005
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- Publication type:
- Report
Sequential assistance of molecular chaperones and transient formation of covalent complexes during protein degradation from the ER.
- Published in:
- Journal of Cell Biology, 2002, v. 158, n. 2, p. 247, doi. 10.1083/jcb.200204122
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- Publication type:
- Article
Atg4b-Dependent Autophagic Flux Alleviates Huntington’s Disease Progression.
- Published in:
- PLoS ONE, 2013, v. 8, n. 7, p. 1, doi. 10.1371/journal.pone.0068357
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- Publication type:
- Article
Hdac6 Knock-Out Increases Tubulin Acetylation but Does Not Modify Disease Progression in the R6/2 Mouse Model of Huntington's Disease.
- Published in:
- PLoS ONE, 2011, v. 6, n. 6, p. 1, doi. 10.1371/journal.pone.0020696
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- Publication type:
- Article
Perturbation with Intrabodies Reveals That Calpain Cleavage Is Required for Degradation of Huntingtin Exon 1.
- Published in:
- PLoS ONE, 2011, v. 6, n. 1, p. 1, doi. 10.1371/journal.pone.0016676
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- Publication type:
- Article
BACE1 and Mutated Presenilin-1 Differently Modulate Aβ40 and Aβ42 Levels and Cerebral Amyloidosis in APPDutch Transgenic Mice.
- Published in:
- Neurodegenerative Diseases, 2007, v. 4, n. 2/3, p. 127, doi. 10.1159/000101837
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- Publication type:
- Article
ER‐mitochondria contacts and cholesterol metabolism are disrupted by disease‐associated tau protein.
- Published in:
- EMBO Reports, 2023, v. 24, n. 8, p. 1, doi. 10.15252/embr.202357499
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- Publication type:
- Article
Emerging Evidences for an Implication of the Neurodegeneration-Associated Protein TAU in Cancer.
- Published in:
- Brain Sciences (2076-3425), 2020, v. 10, n. 11, p. 862, doi. 10.3390/brainsci10110862
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- Publication type:
- Article
ER‐to‐lysosome‐associated degradation of proteasome‐resistant ATZ polymers occurs via receptor‐mediated vesicular transport.
- Published in:
- EMBO Journal, 2018, v. 37, n. 17, p. 1, doi. 10.15252/embj.201899259
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- Publication type:
- Article
BACE-1 is expressed in the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer's disease.
- Published in:
- Journal of Cerebral Blood Flow & Metabolism, 2016, v. 36, n. 7, p. 1281, doi. 10.1177/0271678X15606463
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- Publication type:
- Article
Tau affects P53 function and cell fate during the DNA damage response.
- Published in:
- Communications Biology, 2020, v. 3, n. 1, p. 1, doi. 10.1038/s42003-020-0975-4
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- Publication type:
- Article
Suppression of protein aggregation by chaperone modification of high molecular weight complexes.
- Published in:
- Brain: A Journal of Neurology, 2012, v. 135, n. 4, p. 1180, doi. 10.1093/brain/aws022
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- Publication type:
- Article
β-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins.
- Published in:
- FEBS Journal, 2010, v. 277, n. 6, p. 1503, doi. 10.1111/j.1742-4658.2010.07579.x
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- Publication type:
- Article
Functional and dynamic polymerization of the ALSlinked protein TDP-43 antagonizes its pathologic aggregation.
- Published in:
- Nature Communications, 2017, v. 8, n. 6, p. 1, doi. 10.1038/s41467-017-00062-0
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- Publication type:
- Article
Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model.
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- Journal of Neurochemistry, 2011, v. 119, n. 2, p. 398, doi. 10.1111/j.1471-4159.2011.07435.x
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- Publication type:
- Article
The heat shock response, determined by QuantiGene multiplex, is impaired in HD mouse models and not caused by HSF1 reduction.
- Published in:
- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-88715-5
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- Publication type:
- Article
Chloroquine, the Coronavirus Crisis, and Neurodegeneration: A Perspective.
- Published in:
- Frontiers in Neurology, 2020, v. 11, p. N.PAG, doi. 10.3389/fneur.2020.596528
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- Publication type:
- Article
Amyloid precursor protein truncated at any of the γ-secretase sites is not cleaved to β-amyloid.
- Published in:
- Journal of Neuroscience Research, 1996, v. 46, n. 3, p. 283, doi. 10.1002/(SICI)1097-4547(19961101)46:3<283::AID-JNR1>3.0.CO;2-G
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- Publication type:
- Article
Amyloid β interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.
- Published in:
- Nature Neuroscience, 2000, v. 3, n. 5, p. 460, doi. 10.1038/74833
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- Publication type:
- Article
Deciphering the role of tau in neurodegeneration using Adeno-Associated Viral (AAV) vectors to express human tau in the mouse forebrain.
- Published in:
- 2013
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- Publication type:
- Abstract
Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors.
- Published in:
- Molecular Neurodegeneration, 2010, v. 5, p. 58, doi. 10.1186/1750-1326-5-58
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- Publication type:
- Article
The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease.
- Published in:
- Molecular Neurodegeneration, 2010, v. 5, p. 26, doi. 10.1186/1750-1326-5-26
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- Publication type:
- Article
Inducible mutant huntingtin expression in HN10 cells reproduces Huntington's disease-like neuronal dysfunction.
- Published in:
- Molecular Neurodegeneration, 2009, v. 4, p. 1, doi. 10.1186/1750-1326-4-11
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- Publication type:
- Article
Epithelial growth factor receptor expression influences 5-ALA induced glioblastoma fluorescence.
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- Journal of Neuro-Oncology, 2017, v. 133, n. 3, p. 497, doi. 10.1007/s11060-017-2474-0
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- Publication type:
- Article
Phosphorylation of nuclear Tau is modulated by distinct cellular pathways.
- Published in:
- Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-36374-4
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- Publication type:
- Article
Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression.
- Published in:
- Human Molecular Genetics, 2010, v. 19, n. 8, p. 1528, doi. 10.1093/hmg/ddq026
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- Publication type:
- Article
Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease.
- Published in:
- Human Molecular Genetics, 2010, v. 19, n. 1, p. 65, doi. 10.1093/hmg/ddp467
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- Publication type:
- Article
Sensitive biochemical aggregate detection reveals aggregation onset before symptom development in cellular and murine models of Huntington’s disease.
- Published in:
- Journal of Neurochemistry, 2008, v. 104, n. 3, p. 846, doi. 10.1111/j.1471-4159.2007.05032.x
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- Publication type:
- Article
Insertion of Lysosomal Targeting Sequences to the Amyloid Precursor Protein Reduces Secretion of βA4.
- Published in:
- Journal of Neurochemistry, 1997, v. 68, n. 4, p. 1571, doi. 10.1046/j.1471-4159.1997.68041571.x
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- Publication type:
- Article
Development of a Method for the High-Throughput Quantification of Cellular Proteins.
- Published in:
- ChemBioChem, 2009, v. 10, n. 10, p. 1678, doi. 10.1002/cbic.200900131
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- Publication type:
- Article
Correlation between Blood Monocytes and CSF Tau in Alzheimer's Disease: The Effect of Gender and Cognitive Decline.
- Published in:
- NeuroSci, 2023, v. 4, n. 4, p. 319, doi. 10.3390/neurosci4040026
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- Publication type:
- Article
Tau accumulation in degradative organelles is associated to lysosomal stress.
- Published in:
- Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-44979-7
- By:
- Publication type:
- Article
Tau accumulation in degradative organelles is associated to lysosomal stress.
- Published in:
- Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-44979-7
- By:
- Publication type:
- Article