We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Chlamydia pneumoniae-specific serum immune complexes in patients with multiple sclerosis.
- Authors
Parratt, John; Tavendale, Roger; O'Riordan, Jonathan; Parratt, David; Swingler, Robert
- Abstract
The significance of Chlamydia pneumoniae infection in patients with multiple sclerosis (MS) is unclear. We determined the frequency of serum C. pneumoniae-specific immune complexes in patients with MS, neurological (OND) and healthy controls in a blinded, cross-sectional study. C. pneumoniae immune complexes were detected in 24% (38/156) of MS patients, 16% (11/69) of OND and 15% (77/499) of healthy controls. The odds ratio for all MS patients was 3.95 (95% CI: 2.15 to 7.24; P < 0.0001) accounting for the covariates: sex, age, socio-economic status and area of residence. The odds ratio for recently diagnosed MS patients was 4.33 (95% CI: 1.76 to 10.64; P < 0.001). Systemic C. pneumoniae infection is more frequent in MS patients than the healthy population and occurs early in the course of the disease.
- Subjects
CHLAMYDOPHILA pneumoniae; IMMUNE complexes; IMMUNOGLOBULINS; MULTIPLE sclerosis; DEMYELINATION; PATIENTS
- Publication
Multiple Sclerosis (13524585), 2008, Vol 14, Issue 3, p292
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/1352458507083188