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- Title
Presence of Human Herpesvirus 8 Variants in the Oral Tissues of Human Immunodeficiency Virus-Infected Persons.
- Authors
Di Alberti, L.; Ngui, S. L.; Porter, S. R.; Speight, P. M.; Scully, C. M.; Zakrewska, J. M.; Williams, I. G.; Artese, L.; Piattelli, A.; Teo, C. G.
- Abstract
A 210-bp DNA segment specific to the human herpesvirus 8 (HHV-8) genome was amplified by nested polymerase chain reaction from 10 of 14 archived oral biopsy samples of HIV-positive patients in London who had no evidence of oral Kaposi's sarcoma (KS). Various oral sites were represented. Oral tissues from 20 general dental patients not known to be HIV-infected were negative. When DNA sequences of these products were compared with sequences derived from 5 oral KS tissues of AIDS patients in London and 10 skin biopsies of Italian patients with Mediterranean KS (total number of positive tissues = 25), 11 were found to be unique. DNA and predicted peptide motifs of these sequences were also different from those in 28 of 36 HHV-8-positive lesions previously reported from American and African patients. HHV-8 is tropic for the oral mucosa of HIV-infected persons, and HHV-8 variants, though diverse, may be geographically restricted.
- Publication
Journal of Infectious Diseases, 1997, Vol 175, Issue 3, p703
- ISSN
0022-1899
- Publication type
Article