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- Title
Passive Immunization of the Vagina Protects Mice against Vaginal Transmission of Genital Herpes Infections.
- Authors
Whaley, Kevin J.; Zeitlin, Larry; Barratt, Ruth A.; Hoen, Timothy E.; Cone, Richard A.
- Abstract
Vaginal application of human herpes simplex virus (HSV) antiserum, complement-inactivated antiserum, or IgG purified from antiserum protected mice (P < .001, P < .001, and P < .01, respectively) from visible signs of genital HSV-2 infection after subsequent vaginal inoculation with HSV-2 (10 IDP50). Vaginal application of an anti-HSV-2 monoclonal antibody (MAb III174) also protected mice against infection. This MAb, a neutralizing mouse IgG2A against glycoprotein D, prevented infection as determined by viral shedding from the vagina (P < .05), blocked 50% of visible signs of genital herpes infection at a vaginal dose of -10 ng, and blocked 100% of visible signs of infection at a vaginal dose of 1 μg (P < .001). These results suggest that vaginal applications of anti-HSV antibodies may help prevent sexual transmission of genital herpes infection.
- Publication
Journal of Infectious Diseases, 1994, Vol 169, Issue 3, p647
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/169.3.647