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- Title
Pretreatment with ibuprofen augments circulating tumor necrosis factor-alpha, interleukin-6, and elastase during acute endotoxinemia.
- Authors
Spinas, Giatgen A.; Bloesch, Daniel; Keller, Ulrich; Zimmerli, W.; Cammisuli, Salvatore; Spinas, G A; Bloesch, D; Keller, U; Cammisuli, S
- Abstract
Plasma levels of tumor necrosis factor-α (TNFα), interleukin-1 (IL-1),and interleukin-6 (IL-6) were monitored after intravenous administration of Escherichia coli endotoxin with or without ibuprofen pretreatment to healthy volunteers. Intravenous endotoxin (n = 7) resulted in elevated plasma TNFα concentrations with maximal levelsat 90 min (369 ± 44 pg/ml, P < .001 vs. saline controls, n = 7). The rise in TNF-α was followed by a rise in plasma IL-6 (27 ± 12.8 ng/ml), peaking 30–90 min thereafter. Pretreatment with ibuprofen (n = 6) caused a significant augmentation and temporal shift in cytokine elaboration with maximal TNFα levels(627 ± 136 pg/ml) at 120 min and IL-6 peaks (113 ± 66 ng/ml) at 180 min. In ibuprofen-treated volunteers, the additional increase in TNFα was paralleled by increased levels of circulating elastase. In vitro experiments suggest a causal relationship between these events. Thus, the cyclooxygenaseinhibitor ibuprofen blunts the clinical response to endotoxin but augments circulating cytokine levels and leukocyte degranulation.
- Subjects
IBUPROFEN; ANALYSIS of variance; BLOOD pressure; BODY temperature; CELL physiology; COMPARATIVE studies; ENDOTOXINS; ESCHERICHIA coli; HEART beat; INTERLEUKIN-1; INTERLEUKINS; RESEARCH methodology; MEDICAL cooperation; NEUTROPHILS; PROTEOLYTIC enzymes; REGRESSION analysis; RESEARCH; TUMOR necrosis factors; EVALUATION research; LEUKOCYTE count; THERAPEUTICS
- Publication
Journal of Infectious Diseases, 1991, Vol 163, Issue 1, p89
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/163.1.89