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- Title
Endogenous and Exogenous Reinfections by Haemophilus influenzae in Patients with Chronic Obstructive Pulmonary Disease: The Effect of Antibiotic Treatment on Persistence.
- Authors
Groeneveld, Kees; van Alphen, Loek; Eijk, Paul P.; Visschers, Gert; Jansen, Henk M.; Zanen, H. C.
- Abstract
To analyze whether exacerbations in chronic obstructive pulmonary disease (COPD) coincide with reinfection by Haemophilus influenzae, 16COPD patients were studied longitudinally for 3 years. Exacerbations coincided with reinfection by H. influenzae, either endogenous, by a strain with a DNA fingerprint indistinguishable from the strain previously present but with another major outer membrane protein (MOMP) pattern (2 patients), or exogenous, by a strain with a different DNA fingerprint and MOMP pattern (3 patients). The other patients, remaining in an infectious state without clear exacerbations for longer periods, were persistently infected by a particular H. influenzae strain (median persistence time, 5.5 months; range, 2-23 months). Of8 antibiotic-treated patients, 7 remained infected by H. influenzae with the same DNA fingerprint, although all strains were sensitive to the antibiotics prescribed. Results of the study suggested that exacerbations in COPD patients coincide with endogenous or exogenous reinfection by H. influenzae, persistently infected patients keep the same H. influenzae strain for longer periods, and antibiotic treatment was not effective in eradicating H. influenzae.
- Publication
Journal of Infectious Diseases, 1990, Vol 161, Issue 3, p512
- ISSN
0022-1899
- Publication type
Article