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- Title
ZAP70 expression directly promotes chronic lymphocytic leukaemia cell adhesion to bone marrow stromal cells.
- Authors
Lafarge, Sandrine T.; Li, Hongzhao; Pauls, Samantha D.; Hou, Sen; Johnston, James B.; Gibson, Spencer B.; Marshall, Aaron J.
- Abstract
The article presents a study on correlation of ZAP70 protein expression with the disease chronic lymphocytic leukemia (CLL). It states the analyses of ZAP70 expression in CLL cells and its role in altering B cells which further promotes stromal cell adhesion. It mentions that ZAP70 proteins can alter B cells by affecting its signaling pathways either by its kinase or adaptor functions.
- Subjects
CHRONIC lymphocytic leukemia; PROTEIN expression; STROMAL cells; B cells; CELL adhesion
- Publication
British Journal of Haematology, 2015, Vol 168, Issue 1, p139
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.13063