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- Title
Effects of Low Molecular Weight Sulfated Galactan Fragments From Botryocladia Occidentalis on the Pharmacological and Enzymatic Activity of Spla2 From Crotalus Durissus Cascavella.
- Authors
Toyama, M. H.; Toyama, D. O.; Torres, V. M.; Pontes, G. C.; Farias, W. R. L.; Melo, F. R.; Oliveira, S. C. B.; Fagundes, F. H. R.; Diz Filho, E. B. S.; Cavada, B. S.
- Abstract
Low molecular weight fragments of sulfated galactans (Boc-5 and Boc-10) from the red algae Botryocladia occidentalis significantly inhibited Crotalus durissus cascavella sPLA2 enzymatic activity. Equimolar ratios of sPLA2 to Boc-5 or Boc-10 resulted in allosteric inhibition of sPLA2. Under the conditions tested, we observed that both Boc-5 and Boc-10 strongly decreased edema, myonecrosis, and neurotoxicity induced by native sPLA2.
- Publication
Protein Journal, 2010, Vol 29, Issue 8, p567
- ISSN
1572-3887
- Publication type
Article
- DOI
10.1007/s10930-010-9294-9