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- Title
Impact of number of [<sup>18</sup>F]fluorodeoxyglucose-PET-positive lymph nodes on survival of patients receiving neoadjuvant chemotherapy and surgery for oesophageal cancer.
- Authors
Miyata, H.; Yamasaki, M.; Makino, T.; Tatsumi, M.; Miyazaki, Y.; Takahashi, T.; Kurokawa, Y.; Takiguchi, S.; Mori, M.; Doki, Y.
- Abstract
Background: [18F]fluorodeoxyglucose (FDG)-PET has been used to evaluate the response of primary tumours to neoadjuvant therapy for oesophageal cancer. The clinical significance of the number of PET-positive nodes before and after therapy has not been investigated previously. Methods: [18F]FDG-PET was performed before and 2-3weeks after completion of neoadjuvant chemotherapy to identify the number of PET-positive nodes, and these numbers were assessed in relation to metabolic changes in the primary tumour. Results: Of 302 patients in total, 90 had no PET-positive nodes, 83 had one, 59 had two and 70 patients had three or more positive nodes before therapy. After treatment, the numbers were: none in 207 patients, one in 59, two in 20 and three or more in 16 patients. The number of PET-positive nodes after treatment was influenced by both the number of PET-positive nodes before therapy and the response to preoperative therapy, and correlated with the number of metastatic lymph nodes. Overall survival was longer in patients who had no PET-positive nodes after treatment than in those who had one ormore. Multivariable analysis identified the numbers of PET-positive nodes before and after chemotherapy as independent prognostic factors, together with clinical response, tumour depth and lymph node involvement. Conclusion: The number of PET-positive nodes after treatment correlated with survival in patients with oesophageal cancer who underwent neoadjuvant chemotherapy.
- Subjects
ESOPHAGEAL cancer patients; TREATMENT of esophageal cancer; CANCER chemotherapy; POSITRON emission tomography; ADJUVANT treatment of cancer; ESOPHAGEAL surgery
- Publication
British Journal of Surgery, 2016, Vol 103, Issue 1, p97
- ISSN
0007-1323
- Publication type
Article
- DOI
10.1002/bjs.9965