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- Title
Gleason Score 7 Adenocarcinoma of the Prostate With Lymph Node Metastases.
- Authors
Kryvenko, Oleksandr N.; Gupta, Nilesh S.; Virani, Nilam; Schultz, Daniel; Gomez, Juan; Amin, Ali; Lane, Zhaoli; Epstein, Jonathan I.
- Abstract
Context.-Prostate cancer (PC) with lymph node metastases (LN+) is relatively rare, whereas it is relatively common in disease with a Gleason score (GS) 8 to 10 and virtually never seen in PC with GS 6 or less. It is most variable in GS 7 PC. Objective.-To determine clinicopathologic features associated with GS 7 PC with LN+ compared with a control group without lymph node metastases (LN-). Design.-We analyzed 184 GS 7 radical prostatectomies with LN+ and the same number of LN- Gleasonmatched controls. The LN+ cases were GS 3+4=7 (n=64; 34.8%), GS 4 + 3 = 7 (n ¼ 66; 35.9%), GS 3 + 4 = 7 with tertiary 5 (n = 10; 5.4%), and GS 4 + 3 = 7 with tertiary 5 (n = 44; 23.9%). Results.-The LN+ cases demonstrated higher average values in preoperative prostate-specific antigen (12.2 versus 8.1 ng/mL), percentage of positive biopsy cores (59.1% versus 42.9%), prostate weight (54.4 versus 49.4 g), number of LNs submitted (12.7 versus 9.4), incidence of nonfocal extraprostatic extension (82.6% versus 63.6%), tumor volume (28.9% versus 14.8%), frequency of lymphovascular invasion (78.3% versus 38.6%), intraductal spread of carcinoma (42.4% versus 20.7%), incidence of satellite tumor foci (16.4% versus 4.3%), incidence of pT3b disease (49.5% versus 14.7%), and lymphovascular invasion in the seminal vesicles (52% versus 30%). There were differences in GS 4 patterns and cytology between LN+ and LN- cases, with the former having higher volumes of cribriform and poorly formed patterns, larger nuclei and nucleoli, and more-frequent macronucleoli. All P ≤ .05. Conclusion.-Gleason score 7 PC with LN+ has features highlighting a more-aggressive phenotype. These features can be assessed as prognostic markers in GS 7 disease on biopsy (eg, GS 4 pattern, intraductal spread, cytology) or at radical prostatectomies (all variables), even in men without LN dissection or LN- disease.
- Subjects
ADENOCARCINOMA; CHI-squared test; COMPARATIVE studies; FISHER exact test; LYMPH nodes; METASTASIS; MULTIVARIATE analysis; PROBABILITY theory; PROSTATE; PROSTATE tumors; PROSTATECTOMY; SARCOMA; STATISTICAL hypothesis testing; T-test (Statistics); LOGISTIC regression analysis; RETROSPECTIVE studies; CASE-control method; DATA analysis software
- Publication
Archives of Pathology & Laboratory Medicine, 2013, Vol 137, Issue 5, p610
- ISSN
0003-9985
- Publication type
Article
- DOI
10.5858/arpa.2012-0128-OA