We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Carcinoma of the Breast With Medullary-like Features.
- Authors
Kleer, Celina G.
- Abstract
This case presentation reviews the histologic distinction between pure medullary carcinoma and breast carcinomas with medullary-like features. This particular case prompts us to analyze the relationship among medullary carcinoma, basal-like breast carcinomas and carcinomas associated with germline BRCA1 mutations. In addition to now well-defined features, such as expression of high-molecular-weight cytokeratins and EGFR (epidermal growth factor receptor), basal-like tumors have a deficiency or dysfunction of BRCA1. This association in part explains the histologic features of BRCA1-associated breast cancers. Recent studies in our laboratory demonstrate that BRCA1 protein is regulated by a recently described gene, EZH2. These concepts illustrate the important relationships among histopathologic features; genomic profile; single gene abnormalities, such as BRCA1 and EZH2; and growth regulation in this subset of breast carcinomas.
- Subjects
BREAST cancer; GENETIC mutation; GROWTH factors; GENETIC disorders; MUTAGENESIS
- Publication
Archives of Pathology & Laboratory Medicine, 2009, Vol 133, Issue 11, p1822
- ISSN
0003-9985
- Publication type
Article
- DOI
10.5858/133.11.1822