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- Title
"When the Going Gets Tough": Novel Roles for TRPV4 in Stiffness-induced Phagolysosome Maturation.
- Authors
Estrada-Bernal, Adriana; Sharma, Lokesh; Shah, Faraaz Ali
- Abstract
An editorial is presented on the role of TRPV4 in macrophage function and glucose metabolism during sepsis, suggesting a link between lung stiffness, immune response, and clinical outcomes. Topics include TRPV4-mediated mechanosensing in macrophages, glucose metabolism regulation, and potential implications for sepsis-induced lung injury; and impact of TRPV4 on macrophage phagolysosome maturation, glycolysis regulation, and lactate production in sepsis.
- Subjects
TRPV cation channels; TRP channels
- Publication
American Journal of Respiratory Cell & Molecular Biology, 2024, Vol 70, Issue 6, p431
- ISSN
1044-1549
- Publication type
Article
- DOI
10.1165/rcmb.2024-0070ED