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- Title
Aurantoside K, a New Antifungal Tetramic Acid Glycoside from a Fijian Marine Sponge of the Genus Melophlus.
- Authors
Kumar, Rohitesh; Subramani, Ramesh; Feussner, Klaus-D.; Aalbersberg, William
- Abstract
A new tetramic acid glycoside, aurantoside K, was isolated from a marine sponge belonging to the genus Melophlus. The structure of the compound was elucidated on the basis of spectroscopic analysis (1H NMR, 1H-1H COSY, HSQC, and HMBC, as well as high-resolution ESILCMS). Aurantoside K did not show any significant activity in antimalarial, antibacterial, or HCT-116 cytotoxicity assays, but exhibited a wide spectrum of antifungal activity against wild type Candida albicans, amphotericin-resistant C. albicans, Cryptococcus neoformans, Aspergillus niger, Penicillium sp., Rhizopus sporangia and Sordaria sp.
- Subjects
ANTIFUNGAL agents; TETRAMIC acids; GLYCOSIDES; SPONGES (Invertebrates); NUCLEAR magnetic resonance spectroscopy; CANDIDA albicans
- Publication
Marine Drugs, 2012, Vol 10, Issue 1, p200
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md10010200