We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Peripheral medulloepithelioma: a rare tumor with a potential target therapy.
- Authors
De Pasquale, Maria Debora; De Ioris, Maria Antonietta; Gallo, Angela; Mastronuzzi, Angela; Crocoli, Alessandro; Cozza, Raffaele; Boldrini, Renata
- Abstract
<bold>Background: </bold>Medulloepithelioma (ME) is a rare embryonal tumor predominantly located in the eye or in the central nervous system without an established treatment.<bold>Case Presentation: </bold>We report of a case of a localized peripheral ME treated with conventional and high dose chemotherapy, surgery and local radiotherapy. At relapse, the tumor tissue revealed a different molecular signature compared to the initial tumor mass. This molecular signature revealed a high expression of platelet derived growth factor receptor (PDGFR). Sorafenib plus irinotecan and temozolomide was started with a 5 month progression free survival.<bold>Conclusion: </bold>Our experience suggests a possible role of sorafenib or different PDGFR inhibitors in ME. Targeting treatment could represent an adjuvant and/or alternative therapy for ME and other rare tumors.
- Publication
Journal of Translational Medicine, 2014, Vol 12, Issue 1, p49
- ISSN
1479-5876
- Publication type
journal article
- DOI
10.1186/1479-5876-12-49