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- Title
In vitro Antifungal Activity of the Soap Formulation of the Hexane Leaf Extract of Morinda morindoides (Morinda; Rubiaceae).
- Authors
Touré, A.; Bahi, C.; Bagré, I.; N'Guessan, J. D.; Djaman, A. J.; Coulibaly, A.
- Abstract
Purpose: The aim of this study was to formulate the hexane extract of the leaves of Morinda morindoides (Baker) Milne-Redh (Rubiaceae) as soap and evaluate its antifungal activity against fungal isolates of human origin. Method: The hexane extract of Morinda morindoides was incorporated as an antifungal agent in soap (SMM) and tested against 4 strains of dermatophytes (Candida albicans, Trichophyton rubrum, Trichophyton mentagrophytes and Aspergillus fumigatus) using basic soap (BS) as control. Agar dilution method at serial concentrations ranging from 125 mg/ml to 3.9 mg/ml was used for the determination of the antimicrobial parameters - MIC (minimum inhibitory concentration) and IC50 (concentration producing 50 % inhibition) for these strains. Result: The growth of all fungal strains tested was inhibited by the Morinda morindoides extract soap (SMM) at MIC of 31.25 mg/ml. On the other hand, basic soap (control) inhibited Candida albicans at MIC of 125 mg/ml and at MIC of 62.50 mg/ml for the other 3 strains tested. Thus, SMM showed stronger antifungal activity against the strains tested than the control (basic soap). Conclusion: The hexane extract of Morinda morindoides leaves incorporated in soap exerted antifungal activity against the fungal strains tested. Thus, this soap formulation may find use in the treatment of dermatomycoses.
- Subjects
DERMATOMYCOSES; RUBIACEAE; ANTIFUNGAL agents; MORINDA; HEXANE; SOAP; FUNGAL growth; LEAF morphology; AGAR; THERAPEUTICS
- Publication
Tropical Journal of Pharmaceutical Research, 2010, Vol 9, Issue 3, p237
- ISSN
1596-5996
- Publication type
Article