We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Urinary concentrations of phthalate biomarkers and weight change among postmenopausal women: a prospective cohort study.
- Authors
Díaz Santana, Mary V.; Hankinson, Susan E.; Bigelow, Carol; Sturgeon, Susan R.; Zoeller, R. Thomas; Tinker, Lesley; Manson, Jo Ann E.; Calafat, Antonia M.; Meliker, Jaymie R.; Reeves, Katherine W.
- Abstract
<bold>Background: </bold>Some phthalates are endocrine disrupting chemicals used as plasticizers in consumer products, and have been associated with obesity in cross-sectional studies, yet prospective evaluations of weight change are lacking. Our objective was to evaluate associations between phthalate biomarker concentrations and weight and weight change among postmenopausal women.<bold>Methods: </bold>We performed cross-sectional (N = 997) and longitudinal analyses (N = 660) among postmenopausal Women's Health Initiative participants. We measured 13 phthalate metabolites and creatinine in spot urine samples provided at baseline. Participants' weight and height measured at in-person clinic visits at baseline, year 3, and year 6 were used to calculate body mass index (BMI). We fit multivariable multinomial logistic regression models to explore cross-sectional associations between each phthalate biomarker and baseline BMI category. We evaluated longitudinal associations between each biomarker and weight change using mixed effects linear regression models.<bold>Results: </bold>In cross-sectional analyses, urinary concentrations of some biomarkers were positively associated with obesity prevalence (e.g. sum of di (2-ethylhexyl) phthalate metabolites [ΣDEHP] 4th vs 1st quartile OR = 3.29, 95% CI 1.80-6.03 [p trend< 0.001] vs normal). In longitudinal analyses, positive trends with weight gain between baseline and year 3 were observed for mono-(2-ethyl-5-oxohexyl) phthalate, monoethyl phthalate (MEP), mono-hydroxybutyl phthalate, and mono-hydroxyisobutyl phthalate (e.g. + 2.32 kg [95% CI 0.93-3.72] for 4th vs 1st quartile of MEP; p trend < 0.001). No statistically significant associations were observed between biomarkers and weight gain over 6 years.<bold>Conclusions: </bold>Certain phthalates may contribute to short-term weight gain among postmenopausal women.
- Subjects
PHTHALATE esters; POSTMENOPAUSE; BIOLOGICAL tags; ENDOCRINE disruptors; PLASTICIZERS; CONSUMER goods; OBESITY
- Publication
Environmental Health: A Global Access Science Source, 2019, Vol 18, Issue 1, pN.PAG
- ISSN
1476-069X
- Publication type
journal article
- DOI
10.1186/s12940-019-0458-6