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- Title
The frequency and type of placental histologic lesions in term pregnancies with normal outcome.
- Authors
Bhatti, Gaurav; Romero, Roberto; Kim, Yeon Mee; Pacora, Percy; Benshalom-Tirosh, Neta; Jung, Eun Jung; Yeo, Lami; Panaitescu, Bogdan; Maymon, Eli; Erez, Offer; Hassan, Sonia S.; Kim, Chong Jai; Jaiman, Sunil; Qureshi, Faisal; Jacques, Suzanne M.; Kim, Jung-Sun; Hsu, Chaur-Dong
- Abstract
Objective: To determine the frequency and type of histopathologic lesions in placentas delivered by women with a normal pregnancy outcome. Methods: This retrospective cohort study included placental samples from 944 women with a singleton gestation who delivered at term without obstetrical complications. Placental lesions were classified into the following four categories as defined by the Society for Pediatric Pathology and by our unit: (1) acute placental inflammation, (2) chronic placental inflammation, (3) maternal vascular malperfusion and (4) fetal vascular malperfusion. Results: (1) Seventy-eight percent of the placentas had lesions consistent with inflammatory or vascular lesions; (2) acute inflammatory lesions were the most prevalent, observed in 42.3% of the placentas, but only 1.0% of the lesions were severe; (3) acute inflammatory lesions were more common in the placentas of women with labor than in those without labor; (4) chronic inflammatory lesions of the placenta were present in 29.9%; and (5) maternal and fetal vascular lesions of malperfusion were detected in 35.7% and 19.7%, respectively. Two or more lesions with maternal or fetal vascular features consistent with malperfusion (high-burden lesions) were present in 7.4% and 0.7%, respectively. Conclusion: Most placentas had lesions consistent with inflammatory or vascular lesions, but severe and/or high-burden lesions were infrequent. Mild placental lesions may be interpreted either as acute changes associated with parturition or as representative of a subclinical pathological process (intra-amniotic infection or sterile intra-amniotic inflammation) that did not affect the clinical course of pregnancy.
- Subjects
BLOOD-vessel abnormalities; CHRONIC diseases; INFECTION; INFLAMMATION; LABOR (Obstetrics); LONGITUDINAL method; EVALUATION of medical care; PEDIATRICS; PLACENTA diseases; PREGNANCY; EMBRYOS; DISEASE prevalence; RETROSPECTIVE studies; SEVERITY of illness index; ACUTE diseases
- Publication
Journal of Perinatal Medicine, 2018, Vol 46, Issue 6, p613
- ISSN
0300-5577
- Publication type
Article
- DOI
10.1515/jpm-2018-0055