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- Title
Cord blood galectin-1 and -3 concentrations in term pregnancies with normal restricted and increased fetal growth.
- Authors
Boutsikou, Theodora; Giotaki, Maria; Boutsikou, Maria; Briana, Despina D.; Baka, Stavroula; Piatopoulou, Despoina; Hassiakos, Demetrios; Gourgiotis, Demetrios; Malamitsi-Puchner, Ariadne
- Abstract
Objective: To determine levels of galectins (gal)-1 and -3 (implicated in angiogenesis/immunologic mechanisms) in intrauterine growth restricted (IUGR), large (LGA) and appropriate for gestational age (AGA) pregnancies, as these groups differ in fat mass, angiogenic patterns and immune responses. Methods: Cord-blood (UC) gal-1 and -3 concentrations were measured in 30 IUGR, 30 LGA and 20 AGA singleton full-term infants and their mothers (MS). Results: IUGR, LGA and AGA groups did not differ in gal-1 and -3 concentrations. UC gal-1 levels were lower when mothers were older [b=-0.651, CI 95% -1.186 (-0.116), P=0.018] and UC gal-3 levels were increased when mothers presented gestational diabetes [b=9.836, CI 95% 3.833- (15.839), P=0.002]. In IUGRs MS gal-3 and in LGAs UC gal-1 were decreased in multiparas [b=-5.372, CI 95% -9.584- (-1.161), P=0.014], and [b=-7.540, CI 95% -14.606- (-0.473), P=0.037], respectively. No correlations were found between MS or UC gal-1 and gal-3 concentrations. Conclusions: Lower UC gal-1 levels, when mothers were older, and increased UC gal-3 levels in cases of gestational diabetes, possibly reflect angiogenic activity. In multiparas, decreased MS gal-3 and UC gal-1 levels in IUGR/LGA, respectively, might imply inflammatory response against immunosuppression expected in subsequent pregnancies, as compared to the first one.
- Subjects
IMMUNE system physiology; ACADEMIC medical centers; ANALYSIS of variance; BIRTH size; BIRTH weight; STATISTICAL correlation; CORD blood; FETAL growth retardation; GOODNESS-of-fit tests; LONGITUDINAL method; MULTIVARIATE analysis; NEOVASCULARIZATION; PROTEINS; REGRESSION analysis; STATISTICS; DATA analysis; CASE-control method; DATA analysis software; KRUSKAL-Wallis Test
- Publication
Journal of Perinatal Medicine, 2015, Vol 43, Issue 3, p305
- ISSN
0300-5577
- Publication type
Article
- DOI
10.1515/jpm-2013-0220