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- Title
Effects of Tualang Honey on Reproductive Organs in Ovariectomised Rats.
- Authors
Zaid, Siti Sarah M.; Sulaiman, Siti Amrah; Yunus, Rohaizan; K. N. S., Sirajudeen; Othman, Nor Hayati
- Abstract
BACKGROUND Honey is used traditionally for treatment of various medical problems including peri and postmenopausal complications. OBJECTIVE Hence the objective of this study is to evaluate the effects of Tualang honey on reproductive organs (uterus and vagina) in ovariectomised rats (postmenapousal animal model). MATERIALS AND METHODS Twenty one (21) adult female Sprague Dawley rats were randomly divided into 3 groups (7 animals per group). Animals in group 1 were subjected to sham operation under general anesthesia (CS) and were given distilled water 0.5 ml daily by gavaging for 14 days. Animals of group 2 and 3 underwent bilateral oophorectomy. Animals of Group 2 were given distilled water (CO) and animals of Group 3 received Tualang honey 2 g/kg daily (HO) for a similar duration. All animals were sacrificed 24 hours after the last dose (during diestrous phase). Reproductive organs were removed, weighed and subjected to histological examination. RESULTS The uterine and vaginal relative weights were not significantly different in honey treated and nontreated ovariectomised animals. Both vaginal epithelium and epithelium-muscles thicknesses were significantly improved in honey treated compared to non-treated ovariectomised rats. No significant differences were noted in endometrial and endometrialmuscle thicknesses of the uterus in honey treated and non-treated ovariectomised rats. CONCLUSION This findings support the traditional use of honey in postmenapousal women. Vaginal atrophy and dryness are among the important adverse effects of postmenopausal state. This problem could be overcome by consuming honey.
- Subjects
HONEY; MENOPAUSE; FEMALE reproductive organs; RATS; OVARIECTOMY
- Publication
Malaysian Journal of Medical Sciences, 2007, Vol 14, Issue 1, p116
- ISSN
1394-195X
- Publication type
Article