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- Title
Staphylococcal manipulation of host immune responses.
- Authors
Thammavongsa, Vilasack; Kim, Hwan Keun; Missiakas, Dominique; Schneewind, Olaf
- Abstract
Staphylococcus aureus, a bacterial commensal of the human nares and skin, is a frequent cause of soft tissue and bloodstream infections. A hallmark of staphylococcal infections is their frequent recurrence, even when treated with antibiotics and surgical intervention, which demonstrates the bacterium's ability to manipulate innate and adaptive immune responses. In this Review, we highlight how S. aureus virulence factors inhibit complement activation, block and destroy phagocytic cells and modify host B cell and T cell responses, and we discuss how these insights might be useful for the development of novel therapies against infections with antibiotic resistant strains such as methicillin-resistant S. aureus.
- Subjects
STAPHYLOCOCCAL diseases; IMMUNE response; BLOOD diseases; PHAGOCYTIC function tests; B cells; T cells
- Publication
Nature Reviews Microbiology, 2015, Vol 13, Issue 9, p529
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro3521