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- Title
High‐grade vaginal intraepithelial neoplasia after hysterectomy for high‐grade cervical intraepithelial neoplasia: Is hysterectomy a "definitive" treatment compared to conization?
- Authors
Tanaka, Miyu; Yamanoi, Koji; Taki, Mana; Kitamura, Sachiko; Sunada, Masumi; Chigusa, Yoshitsugu; Horie, Akihito; Yamaguchi, Ken; Hamanishi, Junzo; Mandai, Masaki
- Abstract
Aim: We investigated the frequency of early recurrence of vaginal intraepithelial neoplasia grade 2/3 (VaIN 2/3) (within 2 years) after hysterectomy for cervical intraepithelial neoplasia grade 3 (CIN3). The characteristics of the clinicopathological factors common to them were explored including different surgical methods. Methods: As a retrospective observational study, a total of 647 CIN3 patients were divided into a conization and hysterectomy group (C group, n = 492; H group, n = 155), and HSIL (CIN2/3 or VaIN2/3) recurrence within 2 years after surgery was evaluated. A stratified analyses was performed. Surgical methods were divided into trans‐abdominal, trans‐vaginal, and laparoscopic. Results: The recurrence of VaIN3 was detected in four cases (2.6%) in the H group, which was similar to that of CIN2/3 in the C group, 12 out of 491 patients (2.4%). The patients who developed VaIN3 were significantly older than those who did not (median, VaIN3: 71.0; VaIN1 and less: 48.0; p < 0.0001). All VaIN3 cases were detected within 5 months, although majority of cases were negative in the margin (3/4 cases; margin negative). The method of hysterectomy was not related to the VaIN3 recurrence. Conclusion: For CIN3 patients for whom hysterectomy is the main treatment, VaIN3 can develop in 2.6% within very shortly after operation even if surgical margin was negative. The elder the age, the higher the risk of early recurrence could be. Laparoscopic surgery is considered to be acceptable methods of hysterectomy.
- Subjects
STATISTICS; HYSTERECTOMY; SCIENTIFIC observation; CONFIDENCE intervals; ONE-way analysis of variance; CERVICAL intraepithelial neoplasia; RETROSPECTIVE studies; FISHER exact test; MANN Whitney U Test; VAGINAL tumors; DISEASE relapse; T-test (Statistics); DESCRIPTIVE statistics; CHI-squared test; DATA analysis software; DATA analysis; ODDS ratio; TUMOR grading; LONGITUDINAL method
- Publication
Journal of Obstetrics & Gynaecology Research, 2023, Vol 49, Issue 9, p2361
- ISSN
1341-8076
- Publication type
Article
- DOI
10.1111/jog.15723