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- Title
Borinic Acid Catalysed Reduction of Tertiary Amides with Hydrosilanes: A Mild and Chemoselective Synthesis of Amines.
- Authors
Chardon, Aurélien; Mohy El Dine, Tharwat; Legay, Rémi; De Paolis, Michaël; Rouden, Jacques; Blanchet, Jérôme
- Abstract
A reduction of various aryl, alkyl, and α,β-unsaturated amides with phenylsilane, catalysed by a borinic acid, is reported. The unprecedented reaction was carried out under very mild conditions and led to useful amines. Furthermore, the reaction tolerates a variety of functional groups. Initial investigations implicated that an intermediate diarylhydroborane is involved in the reaction mechanism.
- Subjects
REDUCTION of amides; AMINE synthesis; BORINIC acids; CHEMOSELECTIVITY; REACTION mechanisms (Chemistry)
- Publication
Chemistry - A European Journal, 2017, Vol 23, Issue 9, p2005
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201604802