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- Title
Argatroban as an alternative anticoagulant for patients with heparin allergy during coronary bypass surgery.
- Authors
Ohno, H.; Higashidate, Masafumi; Yokosuka, Tatsuya
- Abstract
Although heparin allergy is a rare but well-documented entity, anticoagulation management for cardiac surgery in patients with the heparin allergy has not been established due to its rarity. Here we report a case that shows our anticoagulation strategy during a coronary bypass operation. A 67-year-old man with unstable angina pectoris developed an urticarial rash 10 h after the second exposure to heparin. Results of the drug lymphocyte stimulation test were positive for porcine heparin, coumadin, and nicorandil. Off-pump coronary bypass surgery was successfully performed with argatroban as an alternative anticoagulant to heparin, with activated clotting time kept over 200 s at the rate of 5 μg/kg per min of argatroban infusion.
- Subjects
CORONARY artery bypass; ANTICOAGULANTS; DRUG allergy; DRUG side effects; HEPARIN; CARDIAC surgery patients
- Publication
Heart & Vessels, 2003, Vol 18, Issue 1, p40
- ISSN
0910-8327
- Publication type
Article
- DOI
10.1007/s003800300006