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- Title
Synthesis of <sup>13</sup>C and <sup>15</sup>N labeled 2,4-dinitroanisole.
- Authors
Jagadish, Bhumasamudram; Field, Jim A.; Chorover, Jon; Sierra ‐ Alvarez, Reyes; Abrell, Leif; Mash, Eugene A.
- Abstract
Syntheses of [13C6]-2,4-dinitroanisole (ring-13C6) from [13C6]-anisole (ring-13C6) and [15N2]-2,4-dinitroanisole from anisole using in situ generated acetyl nitrate and [15N]-acetyl nitrate, respectively, are described. Treatment of [13C6]-anisole (ring-13C6) with acetyl nitrate generated in 100% HNO3 gave [13C6]-2,4-dinitroanisole (ring-13C6) in 83% yield. Treatment of anisole with [15N]-acetyl nitrate generated in 10 N [15N]-HNO3 gave [15N2]-2,4-dinitroanisole in 44% yield after two cycles of nitration. Byproducts in the latter reaction included [15N]-2-nitroanisole and [15N]-4-nitroanisole.
- Subjects
ORGANIC synthesis research; ANISOLE; SPECTRUM analysis; ACETYLENE compounds; NITRIC acid; CHEMICAL yield
- Publication
Journal of Labelled Compounds & Radiopharmaceuticals, 2014, Vol 57, Issue 6, p434
- ISSN
0362-4803
- Publication type
Other
- DOI
10.1002/jlcr.3192