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- Title
Direct oral anticoagulants for deep vein thrombosis among patients with hereditary thrombophilia—A cohort study.
- Authors
Galyfos, George; Chamzin, Alexandros; Charalampopoulos, Georgios; Liasis, Nikolaos; Sigala, Frangiska; Filis, Konstantinos
- Abstract
Objectives: to evaluate direct oral anticoagulants (DOACs) in patients with hereditary thrombophilia and deep venous thrombosis (DVT). Methods: This is a retrospective observational study. Results: In total, 45 patients were treated between 01/2012 and 12/2022 (mean follow-up: 1.5 +/− 0.3 years). The most frequent thrombophilias were heterozygous V Leiden (20%), heterozygous MTHFR C677T (37.8%), heterozygous MTHFR A1298C (24.4%), and hyperhomocysteinemia (26.7%). The patients received rivaroxaban (n = 19), apixaban (n = 15), and dabigatran (n = 11). Three cases presented symptoms' recurrence without evidence of thrombosis' recurrence (two under rivaroxaban and one under apixaban; p >.05). These patients improved under parenteral anticoagulation and were further treated with dabigatran. No other event or major bleeding occurred during the follow-up. The presence of more than two factors was associated with acute recurrence of symptoms (OR = 25.9; 95% CI [1.454–461.262]; p =.026). Conclusions: DOACs seem to be safe and efficient for patients with hereditary thrombophilia and DVT. The presence of more than two thrombophilia factors is associated with a higher risk for symptom recurrence. Although statistically non-significant, symptoms' recurrence was also observed more frequently among patients under anti-Xa inhibitors than antithrombin inhibitors. This should be verified in larger comparative studies.
- Subjects
PYRIDINE; SCIENTIFIC observation; CONFIDENCE intervals; ORAL drug administration; ANTICOAGULANTS; RETROSPECTIVE studies; ACQUISITION of data; BENZIMIDAZOLES; VENOUS thrombosis; RIVAROXABAN; DISEASE relapse; BLOOD diseases; MEDICAL records; DESCRIPTIVE statistics; ODDS ratio; LONGITUDINAL method; HYPERHOMOCYSTEINEMIA
- Publication
Phlebology, 2023, Vol 38, Issue 9, p599
- ISSN
0268-3555
- Publication type
Article
- DOI
10.1177/02683555231199004