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- Title
Susceptibility-based analysis of dynamic gadolinium bolus perfusion MRI.
- Authors
Bonekamp, David; Barker, Peter B.; Leigh, Richard; Zijl, Peter C.M.; Li, Xu
- Abstract
Purpose An algorithm is developed for the reconstruction of dynamic, gadolinium (Gd) bolus MR perfusion images of the human brain, based on quantitative susceptibility mapping (QSM). Methods The method is evaluated in five perfusion scans obtained from four different patients scanned at 3 Tesla, and compared with the conventional analysis based on changes in the transverse relaxation rate ΔR2* and to theoretical predictions. QSM images were referenced to ventricular cerebrospinal fluid (CSF) for each dynamic of the perfusion sequence. Results Images of cerebral blood flow and blood volume were successfully reconstructed from the QSM-analysis, and were comparable to those reconstructed using ΔR2*. The magnitudes of the Gd-associated susceptibility effects in gray and white matter were consistent with theoretical predictions. Conclusion QSM-based analysis may have some theoretical advantages compared with ΔR2*, including a simpler relationship between signal change and Gd concentration. However, disadvantages are its much lower contrast-to-noise ratio, artifacts due to respiration and other effects, and more complicated reconstruction methods. More work is required to optimize data acquisition protocols for QSM-based perfusion imaging. Magn Reson Med 73:544-554, 2015. © 2014 Wiley Periodicals, Inc.
- Publication
Magnetic Resonance in Medicine, 2015, Vol 73, Issue 2, p544
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.25144