We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
DNA-Binding, Photocleavage, and Photodynamic Anti-cancer Activities of Pyridyl Corroles.
- Authors
Liang, Zhen-Hua; Liu, Hai-Yang; Zhou, Rong; Zhang, Zao; Ali, Atif; Han, Bing-Jie; Liu, Yun-Jun; Xiao, Xin-Yan
- Abstract
The DNA-binding, photocleavage, and antitumor activity of three free base pyridyl corroles 1, 2, and 3 have been investigated. The binding affinity toward CT-DNA decreases with increasing number of pentafluorophenyl, whereas the photocleavage activity toward pBR322 DNA becomes more efficient. Singlet oxygen was demonstrated as active species responsible for DNA cleavage. These corroles exhibited high cytotoxicity against three tested cancer cells (Hela, HapG2, and A549) and the cytotoxicity could be further enhanced under irradiation. Intracellular reactive oxygen species level was also monitored using HeLa Cells upon the combined treatment of corroles and light. These corroles could be absorbed by HeLa cells at low concentration. They can induce the decrease of mitochondrial membrane potential and apoptosis of tumor cells under irradiation.
- Subjects
PHOTODYNAMIC therapy; ANTINEOPLASTIC agents; DNA-binding proteins; PYRIDYL compounds; CELL-mediated cytotoxicity; MEMBRANE potential; CANCER cells; APOPTOSIS; DNA metabolism; REACTIVE oxygen species; BIOLOGICAL transport; CELL lines; CELL physiology; DNA; LIGHT; MOLECULAR structure; PORPHYRINS; PHARMACODYNAMICS
- Publication
Journal of Membrane Biology, 2016, Vol 249, Issue 4, p419
- ISSN
0022-2631
- Publication type
journal article
- DOI
10.1007/s00232-016-9879-0