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- Title
Response to Reintroduction of Cetuximab in 5 Patients with Advanced, Chemotherapy-Resistant, Colorectal Cancer without Progressive Disease following First-Line Therapy with a Cetuximab-Containing Regimen.
- Authors
Kaechele, Volker; von Wichert, Goetz; Adler, Guido; Seufferlein, Thomas
- Abstract
Objective: We aimed to determine the response to cetuximab in advanced, chemotherapy-resistant, colorectal cancer following successful first-line therapy with the antibody. Methods: Five patients with metastatic colorectal cancer were treated with a cetuximab-containing regimen after failure of several conventional chemotherapies. Results: These patients had been successfully treated with cetuximab as first-line therapy, and the antibody was then discontinued without disease progression. No severe toxicities were observed upon reexposure to cetuximab. Partial response was noted in 1 patient and tumor stabilization in 2 patients. Conclusion: Reintroduction of cetuximab in combination with chemotherapy is safe and efficacious in patients with colorectal cancer whose tumors were not refractory to a prior cetuximab-containing therapy. Copyright © 2008 S. Karger AG, Basel
- Subjects
CETUXIMAB; DRUG therapy; COLON cancer; EPIDERMAL growth factor; DRUG resistance in cancer cells
- Publication
Oncology, 2008, Vol 74, Issue 3/4, p123
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000151358