Back to matchesWe found a matchYour institution may have access to this item. Find your institution then sign in to continue.TitleEffects of Cycloheximide on Chromatin-Bound and -Unbound PCNA in HeLa Cells.AuthorsSasaki, Kohsuke; Kurose, Akira; Uesugi, Noriyuki; Kato, AkiraAbstractWe examined the effects of cycloheximide on the amount of chromatin-bound and -unbound PCNA subpopulations in HeLa cells. The chromatin-bound PCNA content decreased rapidly in the presence of cycloheximide, whereas the reduction of the total amount of PCNA was minimal even 24 h after the treatment with cycloheximide. From these data, the half-life of PCNA was estimated to be 31.0 h for chromatin-bound PCNA and 276.8 h for the total. Copyright © 1995 S. Karger AG, BaselPublicationOncology, 1995, Vol 52, Issue 5, p419ISSN0030-2414Publication typeArticleDOI10.1159/000227500