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- Title
Enhanced Nitrosourea Cytotoxicity in Cell Culture by Sodium Butyrate.
- Authors
Vu, Vanessa T.; Moy, Bruce C.; Schein, Philip S.; Tew, Kenneth D.
- Abstract
In HeLa S3 cells, sodium butyrate was found to potentiate the cytotoxicity of chloroethylnitrosoureas and alkylating agents in vitro. Using a soft-agar colony-forming assay, 2.5 and 5.0 mM sodium butyrate pretreatment for 22 h increased the cell killing efficacy of both methyl- and chloroethylnitrosoureas by between 30 and 70%. The potentiation of cytotoxicity of bifunctional nitrogen mustards by butyrate was less than that of nitrosoureas, with a 15 30% increased cell kill at 5 mM butyrate. Sodium butyrate per se reduced plating efficiency and caused growth delay if residual levels (calculated at 100 μM for starting concentrations of 5 mM) were not removed by washing prior to plating. Copyright © 1985 S. Karger AG, Basel
- Publication
Oncology, 1985, Vol 42, Issue 5, p317
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000226053