We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Altered luteinizing hormone pulsatility in infertile patients with idiopathic oligoasthenozoospermia.
- Authors
Scaglia, HE; Timossi, CM; Carrere, CA; Zylberstein, C; Colombani, ME; Rey-Valzacchi, G; Aquilano, DR
- Abstract
In a previous study, we demonstrated that oligoasthenozoospermic (OAZ) patients had two types of testosterone response to human chorionic gonadotrophin (HCG) administration: group 1 (OAZ-a) had an altered, monophasic (no first peak) response and group 2 (OAZ-2) had a normal biphasic response. The objective of the present work was to study the luteinizing hormone (LH) pulsatility in OAZ-1 compared with both OAZ-2 and men of proven fertility (PF), in order partly to determine the possible aetiology of the blunted acute testosterone response to HCG in these patients. LH pulsatility was measured in 10 PF, 10 OAZ-1 and 10 OAZ-2 patients, in blood samples taken every 5 min for 6 h in PF, and for 4 h in OAZ patients. LH values were determined by a time-resolved immunofluorometric assay. Frequency and amplitude of the LH pulses were determined by a computer program. LH pulse frequency, expressed as pulses/4 h, was significantly lower in OAZ-1 (1.5 ± 0.97) than in PF (2.4 ± 0.63) and OAZ-2 (2.4 ± 0.84) patients. In six OAZ-1 and two OAZ-2 patients, LH pulsatility was diminished, as they showed less than two pulses/4 h. No statistically significant differences in LH pulse amplitude were found. These results, together with a higher number of OAZ-1 cases found with decreased LH pulsatility, suggest that, at least in a subset of these men, quantitative and/or qualitative alterations of LH secretion might have occurred.
- Publication
Human Reproduction, 1998, Vol 13, Issue 10, p2782
- ISSN
0268-1161
- Publication type
Article
- DOI
10.1093/humrep/13.10.2782