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- Title
Facile synthesis of spiro thiazolidinone via cyclic ketones, amines and thioglycolic acid by MCM-41-Schiff base-CuSO4·5H2O.
- Authors
Hui, Yonghai; Zhang, Yongfei; Luo, Yongyue; Li, Jianpeng; Wang, Yun; Gao, Tianming; Xia, Jialiang; Wang, Sheng; Zhang, Shiqi
- Abstract
Mesoporous MCM-41-supported Schiff base and CuSO4·5H2O (MCM-41@Schiff base-CuSO4·5H2O) catalyzed one-pot three-component condensation of cyclic ketones, amines and thioglycolic acid in toluene. And a series of corresponding spiro thiazolidinone derivatives were obtained in high yields (up to 97%). The synthesized catalyst was characterized via FT-IR, XRD, SEM, TEM and EDS and can be easily recovered by centrifugation and reused at 10 times without any change in catalytic activity. Moreover, the scale-up experiment also demonstrated the practicability of the catalytic system on the condensation. The possible mechanisms pave the way to investigation on the reactions of other cyclic ketones with thioglycolic acid.
- Subjects
THIOGLYCOLIC acid; KETONES; SCHIFF bases; KETONIC acids; CATALYTIC activity; AMINES
- Publication
Research on Chemical Intermediates, 2021, Vol 47, Issue 2, p521
- ISSN
0922-6168
- Publication type
Article
- DOI
10.1007/s11164-020-04283-9