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- Title
ION CHANNEL STRUCTURE: EMERGING STRUCTURE OF THE NICOTINIC ACETYLCHOLINE RECEPTORS.
- Authors
Karlin, Arthur
- Abstract
The conversion of acetylcholine binding into ion conduction across the membrane is becoming more clearly understood in terms of the structure of the receptor and its transitions. A high-resolution structure of a protein that is homologous to the extracellular domain of the receptor has revealed the binding sites and subunit interfaces in great detail. Although the structures of the membrane and cytoplasmic domains are less well determined, the channel lining and the determinants of selectivity have been mapped. The location and structure of the gates, and the coupling between binding sites and gates, remain to be established.
- Subjects
NICOTINIC receptors; ION channels; ACETYLCHOLINE; CELL membranes; CARRIER proteins
- Publication
Nature Reviews Neuroscience, 2002, Vol 3, Issue 2, p102
- ISSN
1471-003X
- Publication type
Article
- DOI
10.1038/nrn731