We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
An efficient and facile synthesis of inhibitors for hepatitis C viral and anti-SARS agents: 4-aryl-5-cyano-1,6-dihydro-2-thiouracils.
- Authors
Rong, Liangce; Yin, Shan; Xia, Sheng; Tao, Shimin; Shi, Yanhui; Tu, Shujiang
- Abstract
One-pot, multicomponent reaction for the synthesis of 4-aryl-5-cyano-1,6-dihydro-2-thiouracils via three-component from aromatic aldehydes, ethyl 2-cyanoacetate and S-benzylisothiourea hydrochloride (methyl carbamimidothioate sulfate) under methanol is described. These compounds have many drug activities, such as anti-hepatitis C viral, anti-Severe acute respiratory syndrome and anti-HIV-1 integrese activity. The advantages of this procedure include the short reaction time, mild reaction conditions and excellent yields.
- Subjects
ANTIVIRAL agents; HEPATITIS C virus; THIOURACIL; ALDEHYDES; SARS treatment; ACETATES; METHANOL; RING formation (Chemistry)
- Publication
Research on Chemical Intermediates, 2012, Vol 38, Issue 3-5, p983
- ISSN
0922-6168
- Publication type
Article
- DOI
10.1007/s11164-011-0434-4