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- Title
The Effect of Thiol-Disulfide Homeostasis on Prognosis in Patients with Early-Stage Non-Small Cell Lung Cancer.
- Authors
KAVAS, Murat; ATİNKAYA BAYTEMİR, Cansel; ALIŞIK, Murat; ÖZTÜRK, Akın; ALPARSLAN BEKİR, Sümeyye; AYDOĞAN EROĞLU, Selma; ERSÖZ KÖSE, Elçin; YALÇINKAYA, İrfan; EREL, Özcan
- Abstract
Objective: Lung cancer has a poor prognosis. Thiol groups with high antioxidant capacity are converted to disulfide bonds through biochemical reactions that neutralize different oxidant compounds. The thiol-disulfide (SH-SS) homeostasis has significant effects on cell mechanisms, transcription, and apoptosis. Here we present the prognostic role of dynamic SH-SS homeostasis in patients operated for NSCLC. Materials and Methods: Patients operating for earlystage NSCLC were prospectively analyzed. SH-SS homeostasis tests were measured using the automated spectrophotometric method. Results: This study enrolled 138 subjects, including 77 patients and 61 healthy controls. Native thiol and total thiol levels were significantly lower in the patient group. The disulfide-to-native thiol ratio, which is an indicator of oxidative stress in SH-SS homeostasis, also reached a level of statistical significance in the patient group (p<0.001). According to the cut-off values (305 and 326.3), the median overall survival rate was significantly shorter in patients with low native thiol and total thiol levels (p<0.001). Conclusions: This study demonstrated decreased native thiol and total thiol levels as well as decreased disulfide levels and SS/SH ratio in early-stage NSCLC. Impaired SH-SS homeostasis may contribute to lung cancer pathogenesis and poor prognosis because of enhanced oxidative stress.
- Subjects
LUNG cancer; THIOLS; HOMEOSTASIS; NON-small-cell lung carcinoma; OVERALL survival
- Publication
Online Turkish Journal of Health Sciences (OTJHS) / Online Türk Sağlık Bilimleri Dergisi, 2023, Vol 8, Issue 1, p122
- ISSN
2459-1467
- Publication type
Article
- DOI
10.26453/otjhs.1226101