We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mutagenic potential of nitroguanidine and nitrosoguanidine in the Drosophila melanogaster sex-linked recessive lethal assay.
- Authors
Gupta, Raj K.; Korte, Don W.; Reddy, Gunda
- Abstract
Nitroguanidine (NG) and its degradation product nitrosoguanidine (NSG) were evaluated for their mutagenic potential by using Drosophila melanogaster sex-linked recessive lethal (SLRL) assay. Following 72 h of feeding exposure, NG and NSG at concentrations of 4-8 μg ml−1 and 15-20 mg ml−1, respectively, were not mutagenic in the test system. The frequencies of mutations for NG and the negative control were 0.188% and 0.096%, respectively. The frequencies of mutations for NSG and the negative control experiments were 0.049% and 0.05%, respectively. The positive control mutation frequencies were 15% and 17.8% for the two assays. The differences between the mutation frequencies of NG and NSG and their negative controls were not significant.
- Subjects
NITROGUANIDINE; MUTAGENS; DROSOPHILA melanogaster; TEST systems; ENZYMES
- Publication
Journal of Applied Toxicology, 1993, Vol 13, Issue 4, p231
- ISSN
0260-437X
- Publication type
Article
- DOI
10.1002/jat.2550130404