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- Title
Network-Based Approach to Repurpose Approved Drugs for COVID-19 by Integrating GWAS and Text Mining Data.
- Authors
Liang, Shuang; Liu, Hui-Min; Liu, Dan-Yang; Lv, Wan-Qiang; Wang, Sheng-Ran; Liu, Jia-Chen; Greenbaum, Jonathan; Shen, Hui; Xiao, Hong-Mei; Deng, Hong-Wen
- Abstract
The coronavirus disease 19 (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has a rapidly increasing prevalence and has caused significant morbidity/mortality. Despite the availability of many vaccines that can offer widespread immunization, it is also important to reach effective treatment for COVID-19 patients. However, the development of novel drug therapeutics is usually a time-consuming and costly process, and therefore, repositioning drugs that were previously approved for other purposes could have a major impact on the fight against COVID-19. Here, we first identified lung-specific gene regulatory/interaction subnetworks (COVID-19-related genes modules) enriched for COVID-19-associated genes obtained from GWAS and text mining. We then screened the targets of 220 approved drugs from DrugBank, obtained their drug-induced gene expression profiles in the LINCS database, and constructed lung-specific drug-related gene modules. By applying an integrated network-based approach to quantify the interactions of the COVID-19-related gene modules and drug-related gene modules, we prioritized 13 approved drugs (e.g., alitretinoin, clocortolone, terazosin, doconexent, and pergolide) that could potentially be repurposed for the treatment of COVID-19. These findings provide important and timely insights into alternative therapeutic options that should be further explored as COVID-19 continues to spread.
- Subjects
COVID-19; SARS-CoV-2; DATA mining; TEXT mining; GENE regulatory networks; DRUG approval
- Publication
Processes, 2022, Vol 10, Issue 2, p326
- ISSN
2227-9717
- Publication type
Article
- DOI
10.3390/pr10020326